When endothelial cells go rogue

Endothelial‐to‐mesenchymal transition (EndMT) is a poorly understood phenomenon that leads to endothelial cells acquiring a variety of different mesenchymal fates. This results in a number of pathological consequences of considerable clinical significance in diseases ranging from cavernous malformations in the brain to tissue fibrosis, atherosclerosis, and cancer. Importantly, while there appears to be a number of different triggers activating EndMT, the final common pathway driving the transition appears to be the same.