Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

H G Brunner; R G Korneluk; M Coerwinkel-Driessen; A MacKenzie; H Smeets; H M Lambermon; B A van Oost; B Wieringa; H H Ropers

doi:10.1007/BF00283680

Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

Hum Genet. 1989 Mar;81(4):308-10. doi: 10.1007/BF00283680.

Authors

H G Brunner¹, R G Korneluk, M Coerwinkel-Driessen, A MacKenzie, H Smeets, H M Lambermon, B A van Oost, B Wieringa, H H Ropers

Affiliation

¹ Department of Human Genetics, University of Nijmegen, Radboud Hospital, The Netherlands.

PMID: 2703233
DOI: 10.1007/BF00283680

Abstract

We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apolipoprotein C-II
Apolipoproteins C / genetics
Chromosomes, Human, Pair 19*
Creatine Kinase / genetics*
Gene Frequency
Genetic Linkage*
Genetic Markers
Humans
Isoenzymes
Myotonic Dystrophy / genetics*
Recombination, Genetic

Substances

Apolipoprotein C-II
Apolipoproteins C
Genetic Markers
Isoenzymes
Creatine Kinase