Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected

J Clin Virol. 2016 Jun:79:77-79. doi: 10.1016/j.jcv.2016.04.011. Epub 2016 Apr 14.

Abstract

Background: All the reports from Angola's 2013 dengue outbreak revealed serotype 1. However, previously dengue serotypes 1-4 have been reported in Africa and in 2014 serotype 4 was reported in Angola.

Objectives: To report dengue serotypes in patients returning from Angola during 2013 outbreak.

Study design: Retrospective, cross-sectional study. We serotyped the dengue by an in house Polymerase Chain Reaction technique in randomly selected cases.

Results: From the 2013 Angola's dengue outbreak we treated 47 adult patients. None had history of past dengue. A combo kit test for dengue revealed positive NS1 antigen in 39 and IgM antibodies in 8. From 17 randomly patients tested by RNA Real Time-PCR, 11 were positive: 7 for DENV-1, 2 for DENV-2, 1 for DENV-3 (co-infected with DENV-1) and 1 for DENV-4. None had a complicated or fatal evolution.

Conclusion: Unlike previous reports the 4 serotypes were detected, and this resulted in a different epidemiological situation, raising the risk of future outbreaks of severe dengue.

Keywords: Angola; Angola’s dengue outbreak; Dengue; Dengue serotype.

MeSH terms

  • Adult
  • Angola / epidemiology
  • Cross-Sectional Studies
  • Dengue / epidemiology*
  • Dengue / virology*
  • Dengue Virus / classification*
  • Dengue Virus / isolation & purification*
  • Disease Outbreaks*
  • Female
  • Genotyping Techniques
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Portugal
  • Retrospective Studies
  • Serogroup*
  • Travel*