Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No-Joon Song; Seri Choi; Prashant Rajbhandari; Seo-Hyuk Chang; Suji Kim; Laurent Vergnes; So-Mi Kwon; Jung-Hoon Yoon; Sukchan Lee; Jin-Mo Ku; Jeong-Soo Lee; Karen Reue; Seung-Hoi Koo; Peter Tontonoz; Kye Won Park

doi:10.1038/nchembio.2081

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Nat Chem Biol. 2016 Jul;12(7):479-81. doi: 10.1038/nchembio.2081. Epub 2016 May 9.

Authors

No-Joon Song¹, Seri Choi², Prashant Rajbhandari³, Seo-Hyuk Chang¹, Suji Kim¹, Laurent Vergnes⁴, So-Mi Kwon¹, Jung-Hoon Yoon¹, Sukchan Lee⁵, Jin-Mo Ku⁶, Jeong-Soo Lee^{7

8}, Karen Reue^{4

9}, Seung-Hoi Koo², Peter Tontonoz^{10

3}, Kye Won Park¹

Affiliations

¹ Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
² Division of Life Sciences, Korea University, Seoul, Korea.
³ Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁵ Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.
⁶ Natural Product Research Team, Gyeonggi Bio-Center, Gyeonggi Institute of Science and Technology Promotion, Suwon, Korea.
⁷ Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
⁸ Major of Functional Genomics, University of Science and Technology, Daejeon, Korea.
⁹ Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
¹⁰ Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, USA.

Abstract

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue, Brown / drug effects*
Adipose Tissue, Brown / metabolism
Adipose Tissue, White / drug effects*
Adipose Tissue, White / metabolism
Animals
Chalcones / chemistry
Chalcones / pharmacology*
DNA-Binding Proteins / antagonists & inhibitors*
DNA-Binding Proteins / metabolism
Diet, High-Fat / adverse effects
Mice
Mice, Inbred C57BL
Mice, Obese
Transcription Factors / antagonists & inhibitors*
Transcription Factors / metabolism

Substances

Chalcones
DNA-Binding Proteins
PRDM4 protein, mouse
Transcription Factors
butein

Associated data

PubChem-Substance/313041192

Abstract

Publication types

MeSH terms

Substances

Associated data

Grants and funding