Distribution of HLA-A, -B and -DRB1 alleles in the Kensiu and Semai Orang Asli sub-groups in Peninsular Malaysia

Hum Immunol. 2016 Aug;77(8):618-619. doi: 10.1016/j.humimm.2016.06.009. Epub 2016 Jun 11.

Abstract

The earliest settlers in Peninsular Malaysia are the Orang Asli population, namely Semang, Senoi and Proto Malays. In the present study, we typed the HLA-A, -B and -DRB1 loci of the Kensiu and Semai Orang Asli sub-groups. Sequence-based HLA typing was performed on 59 individuals from two Orang Asli sub-groups. A total of 11, 18 and 14 HLA-A, -B and -DRB1 alleles were identified, respectively. These data are available in the Allele Frequencies Net Database under the population name "Malaysia Kedah Kensiu" and "Malaysia Pahang Semai".

Keywords: HLA; Orang Asli; Population genetics; Semang; Senoi.

MeSH terms

  • Asian People
  • Base Sequence
  • Databases, Nucleic Acid
  • Gene Frequency
  • Genotype
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-DRB1 Chains / genetics*
  • Histocompatibility Testing
  • Humans
  • Malaysia
  • Molecular Sequence Data
  • Population Groups

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DRB1 Chains