Abstract
Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Carriers / chemistry*
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Drug Screening Assays, Antitumor
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Ferritins / chemistry*
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Gold / administration & dosage*
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Gold / chemistry
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Gold / pharmacology*
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Humans
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Models, Molecular
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Molecular Structure
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Nanoparticles / chemistry*
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Organogold Compounds / administration & dosage
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Organogold Compounds / chemistry
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Organogold Compounds / pharmacology*
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Rats
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Drug Carriers
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Organogold Compounds
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Gold
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Ferritins