Abstract
Neonatal sensory processing (tactile and vestibular function) was tested in 78 rhesus macaques from two experiments. At ages 4-5 years, striatal dopamine D2 receptor binding was examined using positron emission tomography. At ages 5-7 years, adult sensory processing was assessed. Findings were: (a) prenatal stress exposure yielded less optimal neonatal sensory processing; (b) animals carrying the short rh5-HTTLPR allele had less optimal neonatal sensory scores than monkeys homozygous for the long allele; (c) neonatal sensory processing was significantly related to striatal D2 receptor binding for carriers of the short allele, but not for animals homozygous for the long allele; and (d) there was moderate developmental continuity in sensory processing from the neonatal period to adulthood.
© 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Age Factors
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Animals
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Animals, Newborn
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Behavior, Animal / physiology*
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Central Nervous System Depressants / administration & dosage
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Central Nervous System Depressants / adverse effects*
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Ethanol / administration & dosage
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Ethanol / adverse effects*
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Female
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Macaca mulatta / genetics
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Macaca mulatta / metabolism
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Macaca mulatta / physiology*
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Positron-Emission Tomography
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Pregnancy
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Prenatal Exposure Delayed Effects / chemically induced
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Prenatal Exposure Delayed Effects / etiology
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Prenatal Exposure Delayed Effects / metabolism*
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Prenatal Exposure Delayed Effects / physiopathology*
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Receptors, Dopamine D2 / metabolism*
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Serotonin Plasma Membrane Transport Proteins / genetics*
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Stress, Psychological / complications*
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Touch Perception / physiology*
Substances
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Central Nervous System Depressants
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Receptors, Dopamine D2
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Serotonin Plasma Membrane Transport Proteins
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Ethanol