DBS for Obesity

Ruth Franco; Erich T Fonoff; Pedro Alvarenga; Antonio Carlos Lopes; Euripides C Miguel; Manoel J Teixeira; Durval Damiani; Clement Hamani

doi:10.3390/brainsci6030021

DBS for Obesity

Brain Sci. 2016 Jul 18;6(3):21. doi: 10.3390/brainsci6030021.

Authors

Ruth Franco¹, Erich T Fonoff², Pedro Alvarenga³, Antonio Carlos Lopes⁴, Euripides C Miguel⁵, Manoel J Teixeira⁶, Durval Damiani⁷, Clement Hamani^{8

9

10}

Affiliations

¹ Division of Pediatric Endocrinology, Children's Hospital, University of São Paulo Medical School, São Paulo 05403-000, Brazil. [email protected].
² Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
³ Department of Psychiatry, Institute of Psychiatry, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
⁴ Department of Psychiatry, Institute of Psychiatry, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
⁵ Department of Psychiatry, Institute of Psychiatry, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
⁶ Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
⁷ Division of Pediatric Endocrinology, Children's Hospital, University of São Paulo Medical School, São Paulo 05403-000, Brazil. [email protected].
⁸ Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School, São Paulo 01060-970, Brazil. [email protected].
⁹ Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 1R8, Canada. [email protected].
¹⁰ Division of Neuroimaging, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada. [email protected].

Abstract

Obesity is a chronic, progressive and prevalent disorder. Morbid obesity, in particular, is associated with numerous comorbidities and early mortality. In patients with morbid obesity, pharmacological and behavioral approaches often have limited results. Bariatric surgery is quite effective but is associated with operative failures and a non-negligible incidence of side effects. In the last decades, deep brain stimulation (DBS) has been investigated as a neurosurgical modality to treat various neuropsychiatric disorders. In this article we review the rationale for selecting different brain targets, surgical results and future perspectives for the use of DBS in medically refractory obesity.

Keywords: deep brain stimulation; hypothalamus; nucleus accumbens; obesity.

Publication types

Review