Genetics of Bariatric Surgery Outcomes

Endocrinol Metab Clin North Am. 2016 Sep;45(3):623-32. doi: 10.1016/j.ecl.2016.04.011.

Abstract

Outcomes after bariatric surgery can vary widely and seem to have a significant genetic component. Only a small number of candidate gene and genome-wide association studies have analyzed bariatric surgery outcomes. The role of bile acids in mediating the beneficial effects of bariatric surgery implicate genes regulated by the farnesoid X receptor transcription factor.

Keywords: Bariatric surgery; Genetics; NAFLD; Type 2 diabetes mellitus; Weight loss.

Publication types

  • Review

MeSH terms

  • Bariatric Surgery*
  • Bile Acids and Salts
  • Genome-Wide Association Study
  • Humans
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Treatment Outcome
  • Weight Loss / genetics*

Substances

  • Bile Acids and Salts
  • Receptors, Cytoplasmic and Nuclear
  • farnesoid X-activated receptor