Abstract
The toxicity of anti-HIV drugs, 3'-azido-3'-deoxythymidine (zidovudine, AZT), 2',3'-dideoxycytidine (DDC), 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and ribavirin was studied in vitro in murine fetal liver cells (FLC) and in bone marrow cells. These studies indicate that d4T is the least toxic drug and ribavirin is the most toxic agent in both models. However, the murine FLC system was found to be a more sensitive model for the assessment of toxicity of anti-HIV agents towards erythroid progenitor cells as indicated by the IC50 values.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Bone Marrow Cells
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Cells, Cultured
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Colony-Forming Units Assay
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Dideoxynucleosides / toxicity
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Fetus
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HIV / drug effects
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / drug effects*
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Liver / cytology
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Liver / drug effects*
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Liver / pathology
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Mice
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Ribavirin / toxicity
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Zalcitabine* / analogs & derivatives*
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Zidovudine / toxicity
Substances
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Antiviral Agents
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Dideoxynucleosides
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2',3'-dideoxythymidine
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Ribavirin
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Zidovudine
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Zalcitabine
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2',3'-dideoxycytidinene