Abstract
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / metabolism
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Brain / diagnostic imaging*
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Brain / metabolism
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Brain / pathology
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Brain / virology
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Choline / metabolism
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Creatine / metabolism
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Echoencephalography
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Female
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Fetus / diagnostic imaging*
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Fetus / metabolism
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Fetus / pathology
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Fetus / virology
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Glutamic Acid / metabolism
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Glutamine / metabolism
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Inositol / metabolism
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Macaca nemestrina
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Magnetic Resonance Imaging
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Magnetic Resonance Spectroscopy
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Pregnancy
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Pregnancy Complications, Infectious / diagnostic imaging*
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Pregnancy Complications, Infectious / metabolism
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Pregnancy Complications, Infectious / pathology
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RNA, Viral / metabolism
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Ultrasonography, Prenatal
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Zika Virus / genetics
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Zika Virus Infection / diagnostic imaging*
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Zika Virus Infection / metabolism
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Zika Virus Infection / pathology
Substances
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RNA, Viral
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Glutamine
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Aspartic Acid
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Glutamic Acid
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Inositol
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N-acetylaspartate
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Creatine
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Choline