Coping with Loss: Cell Adaptation to Cytoskeleton Disruption

David J McGarry; Michael F Olson

doi:10.1016/j.devcel.2016.09.020

Coping with Loss: Cell Adaptation to Cytoskeleton Disruption

Dev Cell. 2016 Oct 10;39(1):3-4. doi: 10.1016/j.devcel.2016.09.020.

Authors

David J McGarry¹, Michael F Olson²

Affiliations

¹ Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
² Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: [email protected].

PMID: 27728780
DOI: 10.1016/j.devcel.2016.09.020

Abstract

Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish cellular homeostasis.

Publication types

Kommentar

MeSH terms

Cytoskeleton / drug effects
Microtubules / metabolism
Rho Guanine Nucleotide Exchange Factors
cdc42 GTP-Binding Protein / metabolism*
rac1 GTP-Binding Protein / metabolism*

Substances

Rho Guanine Nucleotide Exchange Factors
cdc42 GTP-Binding Protein
rac1 GTP-Binding Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding