Recently Fuhrmann et al published in Transfusion an article on optimization of the NOD/scid mouse model for studying survival kinetics and immune clearance of human platelets in vivo (Transfusion, Apr 18, 2016). An additional unresolved issue concerning this model is whether cross-species incompatibility between human IgG Fc and mouse Fc receptors (FcR) adversely affects antibody-induced platelet clearance. If so, it might be necessary to use mice transgenic for human FcR to optimize the model for study of immune destruction of human blood cells. We used the IgG1 mouse monoclonal 7E3, specific for human GPIIb/IIIa, a humanized variant of 7E3 (c7E3) and c7E3 Fab fragments to show that the inter-species FcR difference impairs clearance of human platelets sensitized with Ig1 antibodies only slightly and cite in vitro studies suggesting that the same is likely to be true of IgG3 antibodies, the second most common pathogenic antibody isotype. Findings made validate use of the NOD/scid mouse model for the study of antibody-mediated clearance of human blood cells.