Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma

Wenting Shang; Chaoting Zeng; Yang Du; Hui Hui; Xiao Liang; Chongwei Chi; Kun Wang; Zhongliang Wang; Jie Tian

doi:10.1002/adma.201604381

Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma

Adv Mater. 2017 Jan;29(3). doi: 10.1002/adma.201604381. Epub 2016 Nov 18.

Authors

Wenting Shang^{1

2}, Chaoting Zeng^{1

2}, Yang Du^{1

2}, Hui Hui^{1

2}, Xiao Liang^{1

2}, Chongwei Chi^{1

2}, Kun Wang^{1

2}, Zhongliang Wang³, Jie Tian^{1

2}

Affiliations

¹ Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
² Beijing Key Laboratory of Molecular Imaging, Beijing, 100190, China.
³ School of Life Science and Technology, Xidian University, Shaanxi, Xi'an, 710071, China.

PMID: 27859713
DOI: 10.1002/adma.201604381

Abstract

One of the most significant challenges in the diagnosis of brain cancer is efficient in vivo imaging using nontoxic nanoprobes. Core-shell gold nanorod@MIL-88(Fe) nanostars are successfully constructed as triple-modality imaging (computed tomography/magnetic-resonance imaging/photoacoustic imaging) nanoprobes that show low cytotoxicity, high contrast, high penetration depth, and high spatial resolution for accurate and noninvasive imaging and diagnosis of gliomas.

Keywords: Au@MIL-88(Fe); gliomas; gold nanorods; metal-organic frameworks; triple modality.

MeSH terms

Glioma
Gold
Humans
Metal-Organic Frameworks
Multimodal Imaging
Nanotubes*

Substances

Metal-Organic Frameworks
Gold