Bacterial Pathogens and the Microbiome

Otolaryngol Clin North Am. 2017 Feb;50(1):29-47. doi: 10.1016/j.otc.2016.08.004.

Abstract

Bacterial pathogens and microbiome alterations can contribute to the initiation and propagation of mucosal inflammation in chronic rhinosinusitis (CRS). In this article, the authors review the clinical and research implications of key pathogens, discuss the role of the microbiome, and connect bacteria to mechanisms of mucosal immunity relevant in CRS.

Keywords: Bacteria; Chronic rhinosinusitis; Culture-independent microbiology; Microbiome; Sinusitis.

Publication types

  • Review

MeSH terms

  • Bacteria* / drug effects
  • Bacteria* / isolation & purification
  • Bacteria* / pathogenicity
  • Chronic Disease
  • Humans
  • Inflammation / immunology
  • Microbiota
  • Nasal Mucosa* / immunology
  • Nasal Mucosa* / microbiology
  • Rhinitis* / immunology
  • Rhinitis* / microbiology
  • Rhinitis* / pathology
  • Rhinitis* / physiopathology
  • Sinusitis* / immunology
  • Sinusitis* / microbiology
  • Sinusitis* / pathology
  • Sinusitis* / physiopathology