Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Biomater Sci. 2016 Dec 20;5(1):38-40. doi: 10.1039/c6bm00683c.

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

MeSH terms

  • Amines / chemistry*
  • Animals
  • Mice
  • Nanostructures / administration & dosage
  • Nanostructures / chemistry*
  • Polymers / chemistry*
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / chemistry

Substances

  • Amines
  • Polymers
  • RNA, Small Interfering