Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma

D J Kerr; T Maughan; E Newlands; G Rustin; N M Bleehen; C Lewis; S B Kaye

doi:10.1038/bjc.1989.230

Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma

Br J Cancer. 1989 Jul;60(1):104-6. doi: 10.1038/bjc.1989.230.

Authors

D J Kerr¹, T Maughan, E Newlands, G Rustin, N M Bleehen, C Lewis, S B Kaye

Affiliation

¹ CRC Department of Medical Oncology, University of Glasgow, UK.

Abstract

Flavone acetic acid (FAA), 8.6 gm-2 has been administered by 6h intravenous infusion to 19 patients with advanced colorectal carcinoma and 15 patients with advanced malignant melanoma. The drug associated toxicity was generally mild and as predicted from the phase I study. No responses were seen in either disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antineoplastic Agents / adverse effects
Antineoplastic Agents / therapeutic use*
Colorectal Neoplasms / drug therapy*
Drug Evaluation
Female
Flavonoids / adverse effects
Flavonoids / therapeutic use*
Humans
Male
Melanoma / drug therapy*
Middle Aged

Substances

Antineoplastic Agents
Flavonoids
flavone acetic acid