Keywords: American College of Cardiology; American Heart Association; Cardiothoracic Surgical Trials Network; CoreValve trials; Dexamethasone for Cardiac Surgery trial; Dual Antiplatelet Therapy trial; EuroSCORE; NOTION trials; P2Y(12) receptor; PARTNER trials; Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin—Thrombolysis in Myocardial Infarction 54 trial; STICH trial; Society of Thoracic Surgeons; Steroids in Cardiac Surgery trial; acute coronary syndromes; aortic stenosis; aspirin; balloon-inflatable prosthesis; bare metal stent; bicuspid aortic valve; bleeding risk; clopidogrel; coronary artery bypass grafting; coronary stent; dexamethasone; drug-eluting stent; dual-antiplatelet therapy; ischemic cardiomyopathy; ischemic mitral regurgitation; left ventricular end-systolic volume index; left ventricular surgical reconstruction; meta-analysis; methylprednisolone; mitral valve repair; myocardial infarction; noncardiac surgery; percutaneous coronary intervention; prasugrel; self-inflating prosthesis; stable ischemic heart disease; stent thrombosis; steroids; surgical aortic valve replacement; surgical risk; systemic inflammatory response syndrome; ticagrelor; transcatheter aortic valve replacement.