Rheumatoid arthritis: TAK-ing the road to suppress inflammation in synovial fibroblasts

Nat Rev Rheumatol. 2017 Mar;13(3):133-134. doi: 10.1038/nrrheum.2016.220. Epub 2017 Jan 12.
No abstract available

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / enzymology
  • Arthritis, Rheumatoid / epidemiology
  • Arthritis, Rheumatoid / metabolism
  • Clinical Trials, Phase II as Topic
  • Cytokines / drug effects
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism
  • Fibroblasts / pathology
  • Humans
  • Lactones / administration & dosage
  • Lactones / therapeutic use
  • MAP Kinase Kinase Kinases / drug effects*
  • Piperidines / administration & dosage
  • Piperidines / therapeutic use
  • Protein Kinase Inhibitors / therapeutic use
  • Pyrimidines / administration & dosage
  • Pyrimidines / therapeutic use
  • Pyrroles / administration & dosage
  • Pyrroles / therapeutic use
  • Resorcinols / administration & dosage
  • Resorcinols / therapeutic use
  • Synovial Membrane / cytology*
  • Synovial Membrane / metabolism

Substances

  • 7-oxozeanol
  • Cytokines
  • Lactones
  • Piperidines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Pyrroles
  • Resorcinols
  • tofacitinib
  • MAP Kinase Kinase Kinases
  • MAP kinase kinase kinase 7