The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.
Keywords: FDA approval; Yersinia pestis; bacteria; bacterial infection; ciprofloxacin; human; infectious diseases; plague; treatment; vector-borne infections; zoonoses.