Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature

M A Balci; G E Pamuk; E Unlu; U Usta; O N Pamuk

doi:10.1177/0961203317691370

Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature

Lupus. 2017 Oct;26(11):1224-1227. doi: 10.1177/0961203317691370. Epub 2017 Feb 2.

Authors

M A Balci¹, G E Pamuk², E Unlu³, U Usta⁴, O N Pamuk¹

Affiliations

¹ 1 Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey.
² 2 Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
³ 3 Department of Radiology, Trakya University Medical Faculty, Edirne, Turkey.
⁴ 4 Department of Pathology, Trakya University Medical Faculty, Edirne, Turkey.

PMID: 28152659
DOI: 10.1177/0961203317691370

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma and four cases of PCNSL have previously been described in association with mycophenolate mofetil. We report the fifth case of PCNSL in a patient with lupus nephropathy while on mycophenolate mofetil treatment.

Keywords: Systemic lupus erythematosus; haematological changes; nephritis.

Publication types

Case Reports
Review

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biopsy
Central Nervous System Neoplasms / chemically induced*
Central Nervous System Neoplasms / diagnosis
Central Nervous System Neoplasms / drug therapy
Central Nervous System Neoplasms / immunology
Diffusion Magnetic Resonance Imaging
Fatal Outcome
Female
Humans
Immunocompromised Host
Immunohistochemistry
Immunosuppressive Agents / adverse effects*
Lupus Erythematosus, Systemic / diagnosis
Lupus Erythematosus, Systemic / drug therapy*
Lupus Erythematosus, Systemic / immunology
Lymphoma, Large B-Cell, Diffuse / chemically induced*
Lymphoma, Large B-Cell, Diffuse / diagnosis
Lymphoma, Large B-Cell, Diffuse / drug therapy
Lymphoma, Large B-Cell, Diffuse / immunology
Middle Aged
Mycophenolic Acid / adverse effects*
Treatment Outcome
Young Adult

Substances

Immunosuppressive Agents
Mycophenolic Acid