Bidentate iminodiacetate modified dendrimer for bone imaging

Lara Pes; Young Kim; Ching-Hsuan Tung

doi:10.1016/j.bmcl.2017.01.059

Bidentate iminodiacetate modified dendrimer for bone imaging

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1252-1255. doi: 10.1016/j.bmcl.2017.01.059. Epub 2017 Jan 20.

Authors

Lara Pes¹, Young Kim², Ching-Hsuan Tung³

Affiliations

¹ Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA.
² Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology, Chonnam National University Medical School, 671, Jebongno, Dong-Gu, Gwangju 501-757, Republic of Korea.
³ Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: [email protected].

Abstract

A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery.

Keywords: Bone; Dendrimer; Fluorescence imaging; Hydroxyapatite; Iminodiacetate.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Administration, Intravenous
Animals
Bone and Bones* / diagnostic imaging
Dendrimers / chemistry*
Diagnostic Imaging*
Fluorescent Dyes / chemistry*
Imino Acids / chemistry*
Mice
Molecular Structure
Polylysine / chemical synthesis*
Polylysine / chemistry
Polylysine / pharmacology

Substances

Dendrimers
Fluorescent Dyes
Imino Acids
Polylysine

Grants and funding

R01 GM094880/GM/NIGMS NIH HHS/United States