Convergent Route to ent-Kaurane Diterpenoids: Total Synthesis of Lungshengenin D and 1α,6α-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione

J Am Chem Soc. 2017 Mar 1;139(8):2932-2935. doi: 10.1021/jacs.7b00140. Epub 2017 Feb 14.

Abstract

The Hoppe's homoaldol reaction of a cyclo-hexenyl carbamate with an aldehyde followed by an unprecedented BF3·OEt2 mediated intramolecular Mukaiyama-Michael-type reaction affords the tetracyclic core structure of ent-kaurane diterpenoids. The usage of this convergent approach for assembling these natural products is demonstrated by the first asymmetric total syntheses of two highly oxidized ent-kaurane diterpenoids: Lungshengenin D and 1α,6α-diacetoxy-ent-kaura-9(11),16-dien-12,15-dione.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diterpenes, Kaurane / chemical synthesis*
  • Diterpenes, Kaurane / chemistry
  • Molecular Structure

Substances

  • 1alpha,6alpha-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione
  • Diterpenes, Kaurane
  • lungshengenin D