Gut microbiota: Implications in Parkinson's disease

Arun Parashar; Malairaman Udayabanu

doi:10.1016/j.parkreldis.2017.02.002

Gut microbiota: Implications in Parkinson's disease

Parkinsonism Relat Disord. 2017 May:38:1-7. doi: 10.1016/j.parkreldis.2017.02.002. Epub 2017 Feb 7.

Authors

Arun Parashar¹, Malairaman Udayabanu²

Affiliations

¹ Jaypee University of Information Technology, Waknaghat, District- Solan, Himachal Pradesh, PIN-173234, India.
² Jaypee University of Information Technology, Waknaghat, District- Solan, Himachal Pradesh, PIN-173234, India. Electronic address: [email protected].

Abstract

Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. Commensal GM modulates brain development and behavior and has been implicated in several neurological disorders like Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, anxiety, stress and much more. A recent study has shown that Parkinson's disease patients suffer from GM dysbiosis, but whether it is a cause or an effect is yet to be understood. In this review, we try to connect the dots between GM and PD pathology using direct and indirect evidence.

Keywords: Antibiotics; Fecal transplant; Germ-free; Gut microbiota; Parkinson's disease; Probiotics.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Cognition / drug effects
Gastrointestinal Microbiome* / drug effects
Humans
Parkinson Disease / microbiology*
Parkinson Disease / physiopathology*
Probiotics / therapeutic use

Substances

Anti-Bacterial Agents