Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

Erika Hasuike; Aya Mizutani Akimoto; Reiko Kuroda; Ko Matsukawa; Yuki Hiruta; Hideko Kanazawa; Ryo Yoshida

doi:10.1039/c7cc00279c

Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

Chem Commun (Camb). 2017 Mar 9;53(21):3142-3144. doi: 10.1039/c7cc00279c.

Authors

Erika Hasuike¹, Aya Mizutani Akimoto², Reiko Kuroda³, Ko Matsukawa², Yuki Hiruta⁴, Hideko Kanazawa⁴, Ryo Yoshida²

Affiliations

¹ Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. [email protected] [email protected] and Faculty of Pharmacy, Keio University, Tokyo, Japan.
² Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. [email protected] [email protected].
³ Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan.
⁴ Faculty of Pharmacy, Keio University, Tokyo, Japan.

PMID: 28246660
DOI: 10.1039/c7cc00279c

Abstract

The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.