Viewing oxidative stress through the lens of oxidative signalling rather than damage

Biochem J. 2017 Mar 7;474(6):877-883. doi: 10.1042/BCJ20160814.

Abstract

Concepts of the roles of reactive oxygen species (ROS) in plants and animals have shifted in recent years from focusing on oxidative damage effects to the current view of ROS as universal signalling metabolites. Rather than having two opposing activities, i.e. damage and signalling, the emerging concept is that all types of oxidative modification/damage are involved in signalling, not least in the induction of repair processes. Examining the multifaceted roles of ROS as crucial cellular signals, we highlight as an example the loss of photosystem II function called photoinhibition, where photoprotection has classically been conflated with oxidative damage.

Keywords: cell signalling; oxidative stress; photoinhibition; photosynthesis; reactive oxygen species.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / biosynthesis
  • Chlorophyll / agonists
  • Chlorophyll / metabolism
  • Chloroplasts / metabolism
  • Chloroplasts / radiation effects
  • Chloroplasts / ultrastructure
  • Fluorescence
  • Light
  • Light Signal Transduction / physiology*
  • NADP / biosynthesis
  • Oxidation-Reduction
  • Oxidative Stress
  • Photosynthesis / physiology*
  • Photosystem II Protein Complex / physiology*
  • Plants / metabolism
  • Plants / radiation effects*
  • Plants / ultrastructure
  • Reactive Oxygen Species / metabolism*

Substances

  • Photosystem II Protein Complex
  • Reactive Oxygen Species
  • Chlorophyll
  • NADP
  • Adenosine Triphosphate