Unique Case of Disseminated Plague With Multifocal Osteomyelitis

Leidy Tovar Padua; Amanda Kamali; Hannah Kim; Nicole M Green; Rachel Civen; Benjamin Schwartz; Paul Krogstad; Jaime Deville; Nava Yeganeh; Debra Lugo; Amira Baker; Priya Soni; Catherine Cho; Natalia Svircic; Sarah Dry; Leanne Seeger; Jessica Lloyd; Grace Deukmedjian; Richard Bowen; Gillian Hale; Sherif R Zaki; Paul Mead; Karin Nielsen-Saines

doi:10.1093/jpids/pix007

Unique Case of Disseminated Plague With Multifocal Osteomyelitis

J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e165-e168. doi: 10.1093/jpids/pix007.

Authors

Leidy Tovar Padua¹, Amanda Kamali^{2

3}, Hannah Kim⁴, Nicole M Green⁵, Rachel Civen³, Benjamin Schwartz³, Paul Krogstad¹, Jaime Deville¹, Nava Yeganeh¹, Debra Lugo¹, Amira Baker¹, Priya Soni¹, Catherine Cho⁶, Natalia Svircic⁶, Sarah Dry⁷, Leanne Seeger⁴, Jessica Lloyd⁸, Grace Deukmedjian⁸, Richard Bowen⁹, Gillian Hale¹⁰, Sherif R Zaki¹⁰, Paul Mead¹¹, Karin Nielsen-Saines¹

Affiliations

¹ Division of Pediatric Infectious Diseases.
² Epidemic Intelligence Service, Division of Scientific Education and Professional Development.
³ Acute Communicable Disease Control, Los Angeles County Department of Public Health, Los Angeles.
⁴ Departments of Radiology.
⁵ Public Health Laboratory, Los Angeles County Department of Public Health, Downey.
⁶ Department of Family Medicine, Northridge Hospital Medical Center, California.
⁷ Pathology and Laboratory Medicine.
⁸ Department of Pediatrics.
⁹ Orthopedic Surgery, David Geffen UCLA School of Medicine, Los Angeles, California.
¹⁰ Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
¹¹ Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado.

PMID: 28379405
DOI: 10.1093/jpids/pix007

Abstract

Plague is a disease caused by Yersinia pestis. Septicemic and pneumonic plague have a high mortality rate if untreated. Here we describe the challenges of accurately diagnosing a nonfatal pediatric case of septicemic plague with involvement of multiple organs; to our knowledge, the first documented case of multifocal plague osteomyelitis.

Keywords: Yersinia pestis; meningitis; multifocal osteomyelitis; plague osteomyelitis; plague septicemia.

Publication types

Case Reports

MeSH terms

Adolescent
Biopsy
Humans
Los Angeles
Male
Osteomyelitis / etiology*
Osteomyelitis / pathology
Plague / complications*
Plague / pathology
Sepsis / microbiology
Sepsis / pathology
Tibia / pathology