Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

AIDS. 2017 Aug 24;31(13):1847-1851. doi: 10.1097/QAD.0000000000001565.

Abstract

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Anti-Retroviral Agents / administration & dosage*
  • Antiretroviral Therapy, Highly Active / methods
  • Child
  • DNA, Viral / blood*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • Humans
  • Male
  • Perinatal Care / methods*
  • Prospective Studies
  • Secondary Prevention / methods*
  • Sustained Virologic Response*
  • Treatment Outcome

Substances

  • Anti-Retroviral Agents
  • DNA, Viral