Abstract
Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.
Keywords:
diabetes; glycogen; insulin; pancreatic β cell.
Copyright © 2017 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / metabolism*
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Diabetes Mellitus, Type 2 / physiopathology
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Glycogen / metabolism*
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Glycogen Storage Disease / blood
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Glycogen Storage Disease / complications
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Glycogen Storage Disease / metabolism*
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Glycogen Storage Disease / physiopathology
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Humans
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Insulin-Secreting Cells / metabolism*
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Insulin-Secreting Cells / pathology
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Signal Transduction