Abstract
Eight new natural products (four new cucurbitane aglycones, hemslepencins A-D (1-4), four new cucurbitane glucosides, hemslepensides F-I (5-8), along with seven known compounds (9-15), were isolated from the roots of Hemsleya pengxianensis. The structures of 1-8 were elucidated using IR, HRESIMS, and NMR. Compound 3 exhibited cytotoxic activity against the human cancer cell lines.
Keywords:
Cucurbitaceae; Hemsleya pengxianensis; cucurbitane triterpenoid; cytotoxic activity.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cucurbitaceae / chemistry*
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Drug Screening Assays, Antitumor
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Glycosides / chemistry*
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Triterpenes
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cucurbitane