Abstract
Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.
MeSH terms
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Animals
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Clonal Evolution*
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Clone Cells
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DNA Copy Number Variations
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DNA, Neoplasm / genetics
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DNA, Neoplasm / immunology*
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Disease Models, Animal
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Heterografts / immunology*
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Heterografts / pathology
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Humans
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Immunocompromised Host*
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Mice
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Neoplasms / genetics
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Neoplasms / immunology*
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Neoplasms / metabolism
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Neoplasms / pathology
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Precision Medicine
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Species Specificity
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Tumor Cells, Cultured