DNA-crowded enzyme complexes with enhanced activities and stabilities

Chem Commun (Camb). 2017 Dec 5;53(97):13059-13062. doi: 10.1039/c7cc07361e.

Abstract

We present a robust and simple method to prepare DNA-crowded enzyme complexes by directly assembling long DNA duplexes on the enzyme surface. DNA-crowded enzyme complexes show boosted substrate turnover numbers, and increased stabilities against various storage conditions. They could be potentially scaled up for applications in biomaterials and biotechnology.