Abstract
The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupling method that provides access to a concise library of honokiol-inspired analogs. Through this work we determined that the inhibitory activity of honokiol is highly dependent on the growth conditions. Further, we identify a series of analogs that display significant potency against oral bacteria leading to the discovery of a potent antimicrobial.
Keywords:
antibiotic; natural product; oral microbiome; oxidative coupling.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteria / drug effects*
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Bacterial Infections / drug therapy
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Bacterial Infections / microbiology*
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Biofilms / drug effects
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / pharmacology*
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Biphenyl Compounds / therapeutic use
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Humans
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Lignans / chemistry*
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Lignans / pharmacology*
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Lignans / therapeutic use
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Microbial Sensitivity Tests
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Stomatitis / drug therapy
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Stomatitis / microbiology*
Substances
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Anti-Bacterial Agents
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Biphenyl Compounds
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Lignans
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honokiol