Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis

Mol Plant. 2018 Apr 2;11(4):523-541. doi: 10.1016/j.molp.2017.12.003. Epub 2017 Dec 19.

Abstract

Light is a key environmental cue that inhibits hypocotyl cell elongation through the blue and red/far-red light photoreceptors cryptochrome- and phytochrome-mediated pathways in Arabidopsis. In contrast, as a pivotal endogenous phytohormone auxin promotes hypocotyl elongation through the auxin receptors TIR1/AFBs-mediated degradation of AUX/IAA proteins (AUX/IAAs). However, the molecular mechanisms underlying the antagonistic interaction of light and auxin signaling remain unclear. Here, we report that light inhibits auxin signaling through stabilization of AUX/IAAs by blue and red light-dependent interactions of cryptochrome 1 (CRY1) and phytochrome B with AUX/IAAs, respectively. Blue light-triggered interactions of CRY1 with AUX/IAAs inhibit the associations of TIR1 with AUX/IAAs, leading to the repression of auxin-induced degradation of these proteins. Our results indicate that photoreceptors share AUX/IAAs with auxin receptors as the same direct downstream signaling components. We propose that antagonistic regulation of AUX/IAA protein stability by photoreceptors and auxin receptors allows plants to balance light and auxin signals to optimize their growth.

Keywords: AUX/IAA proteins; Arabidopsis; auxin; cryptochrome; light; phytochrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / cytology*
  • Arabidopsis / metabolism
  • Arabidopsis / radiation effects
  • Arabidopsis Proteins / chemistry
  • Arabidopsis Proteins / metabolism*
  • Cryptochromes / metabolism*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Indoleacetic Acids / metabolism*
  • Light*
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism*
  • Phytochrome / metabolism
  • Phytochrome B / metabolism*
  • Protein Binding / radiation effects
  • Protein Domains
  • Signal Transduction / radiation effects*

Substances

  • Arabidopsis Proteins
  • CRY1 protein, Arabidopsis
  • Cryptochromes
  • DNA-Binding Proteins
  • IAA1 protein, Arabidopsis
  • Indoleacetic Acids
  • Nuclear Proteins
  • PHYB protein, Arabidopsis
  • Phytochrome
  • Phytochrome B