MeCP2 as an Activator of Gene Expression

Trends Neurosci. 2018 Feb;41(2):72-74. doi: 10.1016/j.tins.2017.11.005.

Abstract

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression / genetics*
  • Genetic Predisposition to Disease*
  • Humans
  • Methyl-CpG-Binding Protein 2 / genetics*
  • Mutation / genetics*
  • Phenotype
  • Rett Syndrome / genetics*

Substances

  • Methyl-CpG-Binding Protein 2