Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation)

PLoS One. 2018 Mar 22;13(3):e0194775. doi: 10.1371/journal.pone.0194775. eCollection 2018.

Abstract

The immunological profiles of human specific IgE (sIgE) and specific IgG4 (sIgG4) vary by genetic predisposition, living conditions in different geographical locations and patient's age. The aim of our study was to analyze sIgE and sIgG4 patterns and their age-dependent changes in patients from the Moscow region. For identifying sIgE and sIgG4 profiles the blood samples from 513 patients aged 6 months to 17 years who were showing symptoms of allergic diseases were analyzed using microarrays containing 31 allergens. The highest sIgE prevalence was observed for birch pollen (32%) among pollen allergens, cat dander (24%) among indoor allergens, and egg whites (21%) among food allergens. The most common sIgG4 response was developed toward egg whites (80% of patients). Age-related elevation was identified for patients with increased sIgE to pollen allergens and indoor allergens (cat or dog dander and house dust mites). For each allergen, the proportion of cases with significant levels of sIgG4 appeared to increase with patients' age. The data on allergen-specific sIgE and sIgG4 prevalence show both general trends and some local special aspects that are indicative for the Moscow region. This information should be useful in terms of epidemiology of allergic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Allergens / analysis*
  • Allergens / classification
  • Bronchial Provocation Tests / methods
  • Bronchial Provocation Tests / statistics & numerical data
  • Child
  • Child, Preschool
  • Female
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / epidemiology*
  • Food Hypersensitivity / immunology
  • Food Hypersensitivity / metabolism
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microarray Analysis
  • Moscow / epidemiology
  • Respiratory Hypersensitivity / diagnosis*
  • Respiratory Hypersensitivity / epidemiology*
  • Respiratory Hypersensitivity / immunology
  • Respiratory Hypersensitivity / metabolism
  • Russia / epidemiology

Substances

  • Allergens

Grants and funding

This work was supported by the Russian Science Foundation (http://rscf.ru/en), Grant No. 14-50-00060. Optimization of the software for analysis of IgG4 profiles was supported by the Program of fundamental research for state academies for the period 2013 – 2020 (http://fano.gov.ru/), subprogram No. 01201363819. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.