Genetic variation in
VAC14
is associated with bacteremia secondary to diverse pathogens in African children
Proc Natl Acad Sci U S A
.
2018 Apr 17;115(16):E3601-E3603.
doi: 10.1073/pnas.1802071115.
Epub 2018 Mar 27.
Authors
James J Gilchrist
1
2
,
Alexander J Mentzer
3
,
Anna Rautanen
3
,
Matti Pirinen
4
,
Salim Mwarumba
5
,
Patricia Njuguna
5
,
Neema Mturi
5
;
Wellcome Trust Case-Control Consortium 2
;
Kenyan Bacteraemia Study Group
;
Thomas N Williams
5
6
,
J Anthony G Scott
5
7
,
Adrian V S Hill
3
8
Collaborators
Adrian V S Hill
,
Thomas N Williams
,
J Anthony G Scott
,
Stephen J Chapman
,
Anna Rautanen
,
Tara C Mills
,
Kirk Rockett
,
Anne W Ndungu
,
Vivek Naranbhai
,
Alex W Macharia
,
Sophie Uyoga
,
Carolyne Ndila
,
Neema Mturi
,
Patricia Njuguna
,
Shebe Mohammed
,
James A Berkley
,
Isaiah Mwangi
,
Salim Mwarumba
,
Barnes S Kitsao
,
Brett S Lowe
,
Susan C Morpeth
,
Iqbal Khandwalla
,
Alex W Macharia
,
Sophie Uyoga
,
Herbert Opi
,
Carolyne Ndila
,
Emily Nyatichi
,
Prophet Ingosi
,
Barnes Kitsao
,
Clement Lewa
,
Johnstone Makale
,
Adan Mohamed
,
Kenneth Magua
,
Mary Njoroge
,
Gideon Nyutu
,
Ruth Mwarabu
,
Metrine Tendwa
,
Thomas N Williams
,
Ismail Ahmed
,
Samuel Akech
,
Alexander Balo Makazi
,
Mohammed Bakari Hajj
,
Andrew Brent
,
Charles Chesaro
,
Hiza Dayo
,
Richard Idro
,
Patrick Kosgei
,
Kathryn Maitland
,
Kevin Marsh
,
Laura Mwalekwa
,
Shalton Mwaringa
,
Charles Newton
,
Mwanajuma Ngama
,
Allan Pamba
,
Norbert Peshu
,
Anna Seale
,
Alison Talbert
,
Thomas N Williams
,
Peter Donnelly
,
Ines Barroso
,
Jenefer M Blackwell
,
Elvira Bramon
,
Matthew A Brown
,
Juan P Casas
,
Aiden Corvin
,
Panos Deloukas
,
Audrey Duncanson
,
Janusz Jankowski
,
Hugh S Markus
,
Christopher G Mathew
,
Colin Na Palmer
,
Robert Plomin
,
Anna Rautanen
,
Stephen J Sawcer
,
Richard C Trembath
,
Ananth C Viswanathan
,
Nicholas W Wood
,
Chris C A Spencer
,
Gavin Band
,
Céline Bellenguez
,
Colin Freeman
,
Garrett Hellenthal
,
Eleni Giannoulatou
,
Matti Pirinen
,
Richard Pearson
,
Amy Strange
,
Zhan Su
,
Damjan Vukcevic
,
Peter Donnelly
,
Cordelia Langford
,
Sarah E Hunt
,
Sarah Edkins
,
Rhian Gwilliam
,
Hannah Blackburn
,
Suzannah J Bumpstead
,
Serge Dronov
,
Matthew Gillman
,
Emma Gray
,
Naomi Hammond
,
Alagurevathi Jayakumar
,
Owen T McCann
,
Jennifer Liddle
,
Simon C Potter
,
Radhi Ravindrarajah
,
Michelle Ricketts
,
Matthew Waller
,
Paul Weston
,
Sara Widaa
,
Pamela Whittaker
,
Ines Barroso
,
Panos Deloukas
,
Christopher G Mathew
,
Jenefer M Blackwell
,
Matthew A Brown
,
Aiden Corvin
,
Chris C A Spencer
Affiliations
1
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom;
[email protected]
.
2
Department of Paediatrics, University of Oxford, Oxford OX3 9DU, United Kingdom.
3
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
4
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
5
Centre for Geographic Medicine Research, Kenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.
6
Department of Medicine, Imperial College London, London W2 1PG, United Kingdom.
7
Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom.
8
The Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
PMID:
29588414
PMCID:
PMC5910872
DOI:
10.1073/pnas.1802071115
No abstract available
Publication types
Letter
Kommentar
MeSH terms
Bacteremia*
Child
Genetic Variation*
Humans
Intracellular Signaling Peptides and Proteins
Membrane Proteins / genetics
Substances
Intracellular Signaling Peptides and Proteins
Membrane Proteins
VAC14 protein, human
Grants and funding
Wellcome Trust/United Kingdom