Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Thorax. 2019 Jan;74(1):87-90. doi: 10.1136/thoraxjnl-2018-211567. Epub 2018 Apr 7.

Abstract

The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

Keywords: cystic fibrosis; infection control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achromobacter / isolation & purification
  • Adult
  • Aerosols
  • Burkholderia / isolation & purification
  • Colony Count, Microbial
  • Cough / microbiology
  • Cross-Sectional Studies
  • Cystic Fibrosis / microbiology*
  • Female
  • Gram-Negative Bacterial Infections / microbiology
  • Gram-Negative Bacterial Infections / transmission*
  • Humans
  • Male
  • Pseudomonas Infections / transmission
  • Pseudomonas aeruginosa / growth & development
  • Sputum / microbiology
  • Staphylococcal Infections / transmission*
  • Staphylococcus aureus / growth & development*
  • Staphylococcus aureus / isolation & purification
  • Stenotrophomonas maltophilia / isolation & purification
  • Time Factors
  • Young Adult

Substances

  • Aerosols