Features and roles of T helper 9 cells and interleukin 9 in immunological diseases

R Yazdani; S Shapoori; M Rezaeepoor; R Sanaei; M Ganjalikhani-Hakemi; G Azizi; W Rae; A Aghamohammadi; N Rezaei

doi:10.1016/j.aller.2018.02.003

Features and roles of T helper 9 cells and interleukin 9 in immunological diseases

Allergol Immunopathol (Madr). 2019 Jan-Feb;47(1):90-104. doi: 10.1016/j.aller.2018.02.003. Epub 2018 Apr 25.

Authors

R Yazdani¹, S Shapoori², M Rezaeepoor², R Sanaei³, M Ganjalikhani-Hakemi⁴, G Azizi⁵, W Rae⁶, A Aghamohammadi¹, N Rezaei⁷

Affiliations

¹ Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
² Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran, Iran.
⁴ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: [email protected].
⁵ Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
⁶ Department of Immunology, MP8, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire SO16 6YD, UK.
⁷ Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: [email protected].

PMID: 29703631
DOI: 10.1016/j.aller.2018.02.003

Abstract

T helper 9 (T_H9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed T_H9 cells. Recently, the role of T_H9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning T_H9 cells and IL-9 as well as their roles in disease. These insights suggest that T_H9 cells are a future target for therapeutic intervention.

Keywords: Allergic; Autoimmunity; Cancer; IL-9; Immunodeficiency; Infections; T(H)9 cells.

Publication types

Review

MeSH terms

Animals
Autoimmunity
Humans
Immune System Diseases / immunology*
Immunotherapy / methods*
Interleukin-9 / immunology*
T-Lymphocytes, Helper-Inducer / immunology*

Substances

Interleukin-9