Abstract
People who inject drugs (PWID) are commonly exposed to hepatitis B virus (HBV) and hepatitis D virus (HDV). We evaluated the prevalence of HDV viremia among hepatitis B surface antigen (HBsAg)-positive PWID (n = 73) using a new quantitative microarray antibody capture (Q-MAC) assay, HDV western blot, and HDV RNA. HDV Q-MAC performed well in this cohort: anti-HDV, 100% sensitivity and specificity; HDV viremia, 61.5% sensitivity and 100% specificity. Hepatitis D viremia was present in 35.6% of HBsAg-positive participants and was more common in those with resolved compared to chronic hepatitis C (5.1% vs 0.6%; adjusted odds ratio, 9.80; P < .0001).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Coinfection / epidemiology
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Coinfection / immunology
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Coinfection / virology
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Cross-Sectional Studies
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Drug Users
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Female
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Hepatitis B / epidemiology
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Hepatitis B / immunology
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Hepatitis B / virology
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Hepatitis B Antibodies / immunology
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Hepatitis B Surface Antigens / immunology
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Hepatitis B virus / immunology
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Hepatitis B virus / pathogenicity
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Hepatitis D / epidemiology*
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Hepatitis D / immunology
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Hepatitis D / virology
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Hepatitis Delta Virus / immunology
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Hepatitis Delta Virus / pathogenicity
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Humans
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Male
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Middle Aged
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Prevalence
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Risk Factors
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San Francisco / epidemiology
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Substance Abuse, Intravenous / immunology
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Substance Abuse, Intravenous / virology*
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Viremia / epidemiology*
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Viremia / immunology
Substances
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens