Choushenosides A-C, three dimeric catechin glucosides from Codonopsis pilosula collected in Yunnan province, China

Phytochemistry. 2018 Sep:153:53-57. doi: 10.1016/j.phytochem.2018.05.012. Epub 2018 Jun 2.

Abstract

Choushenosides A-C, three dimeric catechin glucosides, were isolated from the roots of Codonopsis pilosula cultivated at high elevations in Yunnan province of the People's Republic of China. The structures of these substances were determined by using spectroscopic and chemical methods. Biological evaluation showed that choushenoside C is a dose-dependent inhibitor of SIRT1.

Keywords: Catechin; Choushenosides A-C; Codonopsis pilosula (Campanulaceae); Dimers; SIRT1.

MeSH terms

  • Catechin / chemistry
  • Catechin / isolation & purification*
  • Catechin / pharmacology
  • China
  • Codonopsis / chemistry*
  • Dose-Response Relationship, Drug
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Humans
  • Molecular Conformation
  • Plant Roots / chemistry*
  • Sirtuin 1 / antagonists & inhibitors
  • Sirtuin 1 / metabolism
  • Structure-Activity Relationship

Substances

  • Glucosides
  • Catechin
  • SIRT1 protein, human
  • Sirtuin 1