New aspects of the life cycle of Pneumocystis carinii

Z Parasitenkd. 1977 Mar 29;51(2):213-7. doi: 10.1007/BF00500960.

Abstract

Pneumocystis is recognized as a cause of pneumonitis in vertebrates, including man. So far an extra-cellular life cycle has been proposed; thick-walled cysts are the site of the formation of so-called intracystic bodies. These intracystic bodies are set free and are supposed to develop into free living thin-walled Pneumocysts ("trophic" stage) (Seifert and Pliess, 1960; Vavra and Kucera, 1970; Campbell, 1972). In this paper we present, based on elaborative ultrastructural studies, data on the existence of both intra-cellular and extra-cellular stages of the parasite which result in a new proposal for the life cycle of the parasite. This short communication will be followed by a more detailed description of our observations.

MeSH terms

  • Animals
  • Epithelial Cells
  • Epithelium / parasitology
  • Lung / parasitology*
  • Lung / ultrastructure
  • Microscopy, Electron
  • Pneumocystis / growth & development*
  • Pneumocystis / ultrastructure
  • Pneumonia, Pneumocystis / parasitology
  • Rats