Rapid Viral Symbiogenesis via Changes in Parasitoid Wasp Genome Architecture

Mol Biol Evol. 2018 Oct 1;35(10):2463-2474. doi: 10.1093/molbev/msy148.

Abstract

Viral genome integration provides a complex route to biological innovation that has rarely but repeatedly occurred in one of the most diverse lineages of organisms on the planet, parasitoid wasps. We describe a novel endogenous virus in braconid wasps derived from pathogenic alphanudiviruses. Limited to a subset of the genus Fopius, this recent acquisition allows an unprecedented opportunity to examine early endogenization events. Massive amounts of virus-like particles (VLPs) are produced in wasp ovaries. Unlike most endogenous viruses of parasitoid wasps, the VLPs do not contain DNA, translating to major differences in parasitism-promoting strategies. Rapid changes include genomic rearrangement, loss of DNA processing proteins, and wasp control of viral gene expression. These events precede the full development of tissue-specific viral gene expression observed in older associations. These data indicate that viral endogenization can rapidly result in functional and evolutionary changes associated with genomic novelty and adaptation in parasitoids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptation, Biological
  • Animals
  • Baculoviridae / genetics*
  • Biological Evolution*
  • Gene Expression Regulation, Viral
  • Genome, Insect*
  • Host-Parasite Interactions / genetics*
  • Symbiosis
  • Wasps / genetics
  • Wasps / virology*