Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study

Ye He; Jing Tian; Wendy H Oddy; Terence Dwyer; Alison J Venn

doi:10.1016/j.fertnstert.2018.05.011

Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study

Fertil Steril. 2018 Sep;110(4):596-604.e1. doi: 10.1016/j.fertnstert.2018.05.011.

Authors

Ye He¹, Jing Tian¹, Wendy H Oddy¹, Terence Dwyer², Alison J Venn³

Affiliations

¹ Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
² Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; The George Institute for Global Health, University of Oxford, Oxford, United Kingdom.
³ Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: [email protected].

PMID: 30196944
DOI: 10.1016/j.fertnstert.2018.05.011

Abstract

Objective: To evaluate whether childhood obesity is associated with infertility in women's reproductive-aged life.

Design: Prospective longitudinal study.

Setting: Not applicable.

Intervention(s): None.

Patient(s): A total of 1,544 girls, aged 7-15 years in 1985, and who completed questionnaires at follow-up in 2004-2006 and/or 2009-2011.

Main outcome measure(s): Infertility was defined as having difficulty conceiving (had tried for ≥12 months to become pregnant without succeeding) or having seen a doctor because of trouble becoming pregnant.

Result(s): At ages from 7-11 years, girls at both the lower and upper end of the body mass index (BMI) z score had increased risk of infertility. Compared with normal weight girls, those with obesity at ages 7-11 years were more likely in adulthood to report infertility (adjusted relative risk [aRR] = 2.94, 95% confidence interval [CI] 1.48-5.84), difficulty conceiving (aRR = 3.89, 95% CI 1.95-7.77), or having seen a doctor because of trouble becoming pregnant (aRR = 3.65, 95% CI 1.90-7.02) after adjusting for childhood age, follow-up length, highest parental education, and marital status.

Conclusion(s): Childhood obesity before 12 years of age appears to increase the risk of female infertility in later life.

Keywords: Childhood; body composition; body mass index; infertility; waist-to-height ratio.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Australia / epidemiology
Body Mass Index*
Child
Female
Follow-Up Studies
Humans
Infertility, Female / diagnosis*
Infertility, Female / epidemiology*
Infertility, Female / etiology
Longitudinal Studies
Pediatric Obesity / complications
Pediatric Obesity / diagnosis*
Pediatric Obesity / epidemiology*
Prospective Studies
Time Factors