Abstract
GIPR signaling in adipose tissue plays an important role in HFD-induced insulin resistance and hepatic steatosis in vivo, with no direct effect on fat accumulation, through IL-6 signaling.
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
MeSH terms
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Adipose Tissue / metabolism*
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Animals
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Diabetes Mellitus, Type 2 / metabolism*
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Gastric Inhibitory Polypeptide / metabolism*
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Humans
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Insulin Resistance
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Mice, Knockout
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Obesity / metabolism*
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Receptors, Gastrointestinal Hormone / genetics
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Receptors, Gastrointestinal Hormone / metabolism*
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Signal Transduction
Substances
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Receptors, Gastrointestinal Hormone
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Gastric Inhibitory Polypeptide
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gastric inhibitory polypeptide receptor