An Interrupted Schmidt Reaction: C-C Bond Formation Arising from Nitrilium Ion Capture

Org Lett. 2018 Oct 19;20(20):6354-6358. doi: 10.1021/acs.orglett.8b02531. Epub 2018 Oct 2.

Abstract

The rerouting of the nitrilium ion formed in the Schmidt reaction of ketones and TMSN3 to encompass C-C bond formation with an electron-rich aromatic group is reported. Thus, when the reaction is carried out in HFIP using AlCl3 or AlBr3 as the promoter, imines, iminium ions, or enamide derivatives are obtained through one-pot procedures. The scope and possible mechanisms of these new transformations are considered.

Publication types

  • Research Support, Non-U.S. Gov't