Learning Compact q -Space Representations for Multi-Shell Diffusion-Weighted MRI

IEEE Trans Med Imaging. 2019 Mar;38(3):834-843. doi: 10.1109/TMI.2018.2873736. Epub 2018 Oct 4.

Abstract

Diffusion-weighted MRI measures the direction and scale of the local diffusion process in every voxel through its spectrum in q -space, typically acquired in one or more shells. Recent developments in microstructure imaging and multi-tissue decomposition have sparked renewed attention in the radial b -value dependence of the signal. Applications in motion correction and outlier rejection, therefore, require a compact linear signal representation that extends over the radial as well as angular domain. Here, we introduce SHARD, a data-driven representation of the q$ -space signal based on spherical harmonics and a radial decomposition into orthonormal components. This representation provides a complete, orthogonal signal basis, tailored to the spherical geometry of q -space, and calibrated to the data at hand. We demonstrate that the rank-reduced decomposition outperforms model-based alternatives in human brain data, while faithfully capturing the micro- and meso-structural information in the signal. Furthermore, we validate the potential of joint radial-spherical as compared with single-shell representations. As such, SHARD is optimally suited for applications that require low-rank signal predictions, such as motion correction and outlier rejection. Finally, we illustrate its application for the latter using outlier robust regression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Brain / diagnostic imaging
  • Diffusion Magnetic Resonance Imaging / methods*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Image Processing, Computer-Assisted / methods*
  • Regression Analysis