Abstract
Uterine carcinosarcomas are rare tumors that account for less than 5% of all uterine malignancies. These tumors (previously called malignant mixed Müllerian tumors) are dedifferentiated carcinomas that comprise carcinomatous and sarcomatous elements and arise from a single malignant clone. They are considered a high-risk variant of endometrial adenocarcinoma because carcinosarcomas share more similarities in epidemiology, risk factors, and clinical behavior with endometrial carcinoma than with uterine sarcomas. The clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma will be discussed in this review.
Keywords:
Chemotherapy; Endometrial cancer; Sarcoma.
© 2018 S. Karger GmbH, Freiburg.
MeSH terms
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Carcinosarcoma / diagnosis*
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Carcinosarcoma / epidemiology
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Carcinosarcoma / pathology
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Carcinosarcoma / therapy
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Chemotherapy, Adjuvant / methods
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Endometrium / diagnostic imaging
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Endometrium / pathology
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Female
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Gynecologic Surgical Procedures / methods
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Humans
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Incidence
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Magnetic Resonance Imaging
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Minimally Invasive Surgical Procedures / methods
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Mixed Tumor, Mullerian / diagnosis*
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Mixed Tumor, Mullerian / epidemiology
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Mixed Tumor, Mullerian / pathology
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Mixed Tumor, Mullerian / therapy
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Neoplasm Recurrence, Local / diagnosis*
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Neoplasm Recurrence, Local / epidemiology
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / therapy
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Patient Selection
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Prognosis
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Radiotherapy, Adjuvant / methods
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Survival Rate
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Uterine Neoplasms / diagnosis*
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Uterine Neoplasms / epidemiology
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Uterine Neoplasms / pathology
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Uterine Neoplasms / therapy