Abstract
We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkadienes / chemistry*
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Allyl Compounds / chemical synthesis*
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Catalysis
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Chemistry Techniques, Synthetic / methods
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Coordination Complexes / chemistry
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Palladium / chemistry
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Phosphines / chemical synthesis
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Phosphines / chemistry*
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Stereoisomerism
Substances
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Alkadienes
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Allyl Compounds
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Coordination Complexes
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Phosphines
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Palladium