RAB27A is an independent prognostic factor in clear cell renal cell carcinoma

Biomark Med. 2019 Mar;13(4):239-247. doi: 10.2217/bmm-2018-0336. Epub 2019 Jan 21.

Abstract

Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC).

Materials & methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated.

Results: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036).

Conclusion: RAB27A is an independent prognostic factor in CCRCC.

Keywords: RAB27A; RAB27B; T stage; clear cell; intensity; metastasis; nuclear grade; progression; renal cell carcinoma; tumor.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Renal Cell / metabolism
  • Carcinoma, Renal Cell / secondary*
  • Carcinoma, Renal Cell / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / metabolism
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / surgery
  • Prognosis
  • Survival Rate
  • rab GTP-Binding Proteins / metabolism*
  • rab27 GTP-Binding Proteins / metabolism*

Substances

  • Biomarkers, Tumor
  • rab27 GTP-Binding Proteins
  • RAB27A protein, human
  • Rab27B protein, human
  • rab GTP-Binding Proteins